![]() ![]() ![]() ![]() NOTE: Maintenance doses should be based on lean body weight, clinical response, and renal function. Patients with moderate-severe renal insufficiency should receive smaller loading doses than patients with normal renal function due to a reduced volume of distribution. NOTE: In patients with undetectable serum digoxin concentrations, the total loading dose should be based on lean body weight and clinical response, and divided into several doses administered at 4- to 8-hour intervals. For ventricular rate control in patients with chronic atrial fibrillation and/or atrial flutter† or for the treatment of narrow-complex paroxysmal supraventricular tachycardia (PSVT)† or for paroxysmal supraventricular tachycardia (PSVT) prophylaxis† in patients without a delta wave on ECG during sinus rhythm. ![]()
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